What Is DNA Methylation Array Analysis?
DNA methylation arrays measure the methylation level at hundreds of thousands of CpG sites across the genome. The Illumina Infinium platform generates a reproducible, standardized readout of the epigenetic layer linking genotype, environment, aging, and disease.
What Can You Do with Methylation Microarrays?
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Discover biomarkers, identifying differentially methylated positions and regions between groups.
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Measure biological age, including epigenetic aging clock estimations from methylation profiles.
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Screen at scale with cost-effective profiling for large cohorts and populations.
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Work with FFPE-derived samples on both EPIC v2 and MSA.
| MethylationEPIC v2.0 | Methylation Screening Array (MSA) | |
| CpG sites | 935,000 | 269,094 |
| Samples per BeadChip | 8 Partial samples accepted; contact our team for more details. |
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| Design focus | Genome-wide discovery | Validated trait-association sites |
| Ideal use |
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| Chemistry | Infinium HD Methylation Assay | Infinium EX Methylation Assay |
| Sample scale | Discovery-based projects | Large cohorts/high-throughput projects |
| FFPE compatible? | Yes (additional charge)* | Yes (additional charge)* |
| Sample type | gDNA* | gDNA* |
| Total amount | >0.5 µg | >0.3 µg |
| Concentration | >13 ng/µl | >13 ng/µl |
| A260/280 | >1.5 | >1.5 |
| A260/230 | >1.0 | >1.0 |
*Non-degraded, non-amplified gDNA required. FFPE-derived samples can be accepted with additional charge for processing.
Coverage & Overlap
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Overlap figures reflect probes mapped in the overlap analysis (930,301 MethylationEPIC v2.0 probes mapped); the array contains ~935,000 CpG sites in total.
Previously validated trait-associated content on Infinium Methylation Screening Array
| Development / aging | 102,533 | Neurological diseases | 8,874 |
| Environmental exposures | 44,043 | Body features | 8,109 |
| Inflammation / autoimmune | 41,894 | Psychiatric disorders | 7,280 |
| Ancestry | 31,843 | Cardiovascular disease | 7,007 |
| Sex | 23,806 | Reproductive biology / health | 6,999 |
| Infectious disease | 14,844 | Neurodegenerative diseases | 4,733 |
| Metabolic disease | 13,739 | Lung / respiratory diseases | 1,748 |
| Rare genetic disorders | 13,429 | Renal disease | 982 |
DNA Methylation Array Data from Psomagen
Why Psomagen?
Rapid Turnaround
For standard runs, receive your methylation data within 3-4 weeks from QC.
Epigenetic Aging Clock
Complimentary epigenetic aging clock analysis available upon request.
Superior Data Quality
Stringent quality control at every step delivers consistent, reproducible, publication-ready results.
Widely-Used Technology
Validated CpG probes, high reproducibility, and standardized data.
Cost Effective at Scale
MSA is optimized for large-sample, high-throughput screening.
PhD-Level Support
Consultation from study design through interpretation.
Start Your Order
Request a Consultation
A specialist will scope the right platform and study design for your project.
Place Order & Ship Samples
View our sample storage and shipping guidelines for more details.
QC & Data Delivery
Deliverables include a full analysis report.
Beyond Methylation Arrays
Microarray isn't the only option for your epigenetic research! Our labs offer a broad portfolio of possible solutions, ensuring you pick the technology that's right for your research.
