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Omics Research

Whole-Genome Sequencing

Sequence an entire human, mouse, rat, or other non-human genome quickly and accurately via US-based, massively parallel, next-generation sequencing (NGS).

Let's Talk About WGS

What is Whole-Genome Sequencing?


Whole-genome sequencing (WGS) is the process of determining the order of bases (Adenine, Guanine, Thymine, or Cytosine) of all DNA in any living organism. 


This can be achieved from a single sample using a single, massively parallel process known as next-generation sequencing (NGS).


Why is Whole-Genome Sequencing Important?


The ability to characterize an entire organism’s genome offers possibilities in all fields of science. 


WGS aids research in infectious disease, microbiology, immunology, inherited disease, oncology, reproductive health, forensics, and more. 


It can be used to identify new disease targets, diagnose inherited disorders, and help predict who will benefit from a given therapy.

What Can You Do?

Process both RUO and Clinical Samples

Access both research-use-only and CAP/CLIA services.

Get Analytics & Bioinformatics

Maximize insights with our dedicated bioinformatics team and numerous analysis options.

Offer Precision Medicine

Introduce new ways to prevent, diagnose, and treat disease on a personalized level.

Tools for WGS

De Novo Sequencing
  • Best for:
    Sequencing and assembling genetic material without an existing reference sequence

  • Benefits:
    The consensus sequence is used in advanced data analysis such as gene prediction and annotation

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DNA Resequencing
  • Best for:
    Aligning WGS data with previously known reference sequence and gene annotation data

  • Benefits:
    Whole-genome mapping and annotated reporting with a much more straightforward data analysis workflow

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Low-Pass Sequencing
  • Best for:
    WGS at a lower sequencing depth, typically targeting 0.5-1X coverage of the genome; used in genome-wide association studies (GWAS), high-throughput population screening methods, and polygenic risk score calculation

  • Benefits:
    Simplified library preparation and reduced sequencing depth for reduced costs and a high-level, genome-wide screen

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Clinical Whole-Genome Sequencing
  • Best for:
    CLIA-certified, CAP-accredited assay validated to provide human genome-wide sequencing data for use in clinical care

  • Benefits:
    High-quality library preparation with or without amplification, a 30X mean depth of coverage, and clinically relevant, annotated gene reports

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Ready for the Next Step?

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PSO Comprehensive!

What forms of whole-genome sequencing will get you the insights you need?

Ask Our Experts

WGS Is Only the Beginning

While WGS is the most comprehensive approach, you may have cost concerns or a very specific question. Ask about our full list of other NGS methods and get exactly what you need.

Whole-Exome Sequencing

A way to study the 2% of the genome that contains 85% of known genetic variants. Gain efficiency through top tools and technologies that focus on the exome, a key player in numerous disease states.

More on WES
Targeted Sequencing

For investigating a specific region of DNA or asking a pointed research question. Choose advanced solutions for targeted sequencing including amplicon and hybrid capture technologies.

More on Targeted Sequencing
RNA Sequencing

How to access the wealth of data in “the other nucleic acid.” Look to the transcriptome for a more direct view of what is being expressed and affecting patient health. [See Solutions]

More on RNA Seq

The best techniques for analyzing masses of biological data. Draw meaningful conclusions and uncover insights that help determine gene and protein evolution and function.

More on Bioinformatics