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What is Whole-Genome Sequencing?
Whole-genome sequencing (WGS) is the process of determining the order of bases (Adenine, Guanine, Thymine, or Cytosine) of all DNA in any living organism.
This can be achieved from a single sample using a single, massively parallel process known as next-generation sequencing (NGS).
Why is Whole-Genome Sequencing Important?
The ability to characterize an entire organism’s genome offers possibilities in all fields of science.
WGS aids research in infectious disease, microbiology, immunology, inherited disease, oncology, reproductive health, forensics, and more.
It can be used to identify new disease targets, diagnose inherited disorders, and help predict who will benefit from a given therapy.
What Can You Do?
Process both RUO and Clinical Samples
Access both research-use-only and CAP/CLIA services.
Get Analytics & Bioinformatics
Maximize insights with our dedicated bioinformatics team and numerous analysis options.
Offer Precision Medicine
Introduce new ways to prevent, diagnose, and treat disease on a personalized level.
Tools for WGS
De Novo Sequencing
- Best for:
WGS at a lower sequencing depth, typically targeting 0.5-1X coverage of the genome; used in genome-wide association studies (GWAS), high-throughput population screening methods, and polygenic risk score calculation
Simplified library preparation and reduced sequencing depth for reduced costs and a high-level, genome-wide screen
Clinical Whole-Genome Sequencing
- Best for:
CLIA-certified, CAP-accredited assay validated to provide human genome-wide sequencing data for use in clinical care
High-quality library preparation with or without amplification, a 30X mean depth of coverage, and clinically relevant, annotated gene reports
Request a Consultation or Quote
Get in touch with your local field team and start designing a project. We’ll help drive your research forward with the right tools for your investigative needs.
Create, Manage and Track Your Project
At this step you'll be able to keep an eye on all the various methods and platforms we’re using to ensure your starting material will produce the most in-depth information possible. It’s easy to get in touch with us if you have a question or concern.
Get Your Data and Analysis Reports
Securely access your raw data and view detailed analyses specific to your scientific question all in one place. Then reach out to our bioinformatics scientists to dig deeper into the results.
Customer Publications and Other Resources
Parastagonospora nodorum and Related Species in Western Canada: Genetic Variability and Effector Genes
Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations
WGS Is Only the Beginning
While WGS is the most comprehensive approach, you may have cost concerns or a very specific question. Ask about our full list of other NGS methods and get exactly what you need.