What Is the Exome?
Exons are the sections of the genome that are transcribed into mRNA and translated into proteins. Altogether, the exons make up the exome — about 2% of the total genome.
It is a preferred tool for understanding patient health histories and diagnoses, as well as testing at-risk family members.
Why Is Studying the Exome Important?
Most (about 85%) of known genetic variants that contribute to disease occur in the exonic regions.
Through a gene sequencing approach targeting this relatively small percentage of the genome, scientists can learn about the majority of clinically relevant genetic variations that affect protein coding.
What Can You Do?
Maximize Your Budget
Sequence ~2% of the genome and study ~85% of known genetic variants.
Find Rare Variants
Rely on Psomagen's CLIA-validated protocols for WES at 50x minimum coverage.
Process Clinical Samples
Discover rare transcripts more easily with the greater depth and coverage afforded by sequencing far less DNA than WGS.
Offer Precision Medicine
Introduce new ways to prevent, diagnose, and treat disease on a personalized level.
Technologies Used for Whole-Exome Sequencing
Whole-Exome Sequencing Panels
Disease and biomarker discovery applications; mapping specific disease-causing mutations against a reference genome
Provides a large amount of information about the genome while restricting the analyses specifically to the regions that code for proteins
Quotes From Our Clients
We used Psomagen to conduct whole exome next-generation sequencing services using multiple tissues derived from various mouse strains. The service has been very effective and timely, and we have achieved high-quality and reproducible results. The QC steps are easy to follow and the price is reasonable. Overall the service is good value for money.
Fengyi Wan, Ph.D.
Johns Hopkins University
Why Our Clients Choose Psomagen
Superior Data Quality
Exceeds manufacturer benchmarks
Starting at one week for sequencing projects
Sequencing and customer support in Rockville, MD
Ph.D. Level Support
Expert assistance every step of the way, with real-time project updates through our online system
Increase scalability and improve reproducibility
CLIA-Certified, CAP-Accredited Labs
Clinical research options available (inquire for more information)
Complete Sequencing Solutions
From extraction to data analysis, with many sample types accepted