Whole-Exome Sequencing Services

What is the Exome?

Exons are the sections of the genome that are transcribed into mRNA and translated into proteins. Altogether, the exons make up the exome — about 2% of the total genome.

Why Is Studying the Exome Important?

Most (or around 85%) of known genetic variants that contribute to disease occur in the exonic regions.

Through a gene sequencing approach targeting this relatively small percentage of the genome, scientists can learn about the majority of clinically relevant genetic variations that affect protein coding.

What Can You Do?

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Maximize Your Budget

Sequence ~2% of the genome and study ~85% of known genetic variants.

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Find Rare Variants

Discover rare transcripts more easily with the greater depth and coverage afforded by sequencing far less DNA than WGS.

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Process Clinical Samples

Rely on Psomagen’s CLIA-validated protocols for WES at 50x minimum coverage.

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Offer Precision Medicine

Introduce new ways to prevent, diagnose, and treat disease on a personalized level.

Tools for WES

Whole-Exome Sequencing Panels

Best for:
Disease and biomarker discovery applications; mapping specific disease-causing mutations against a reference genome
Benefits:
Provides a large amount of information about the genome while restricting the analyses specifically to the regions that code for proteins

Clinical Whole-Exome Sequencing

Best for:
CLIA-certified, CAP-accredited assay validated to provide protein-coding gene sequence data for use in clinical management of patients
Benefits:
Quality management of the end-to-end process from patient sample to analysis; high-quality library preparation and hybrid capture enrichment; 50X mean depth of coverage; clinically-relevant annotated gene reports

Quotes From Our Clients

"We used Psomagen to conduct whole exome next-generation sequencing services using multiple tissues derived from various mouse strains. The service has been very effective and timely, and we have achieved high-quality and reproducible results. The QC steps are easy to follow and the price is reasonable. Overall the service is good value for money."

Fengyi Wan, Ph.D.

Johns Hopkins University

Ordering & Data Delivery

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Request a Consultation or Quote

Get in touch with your local field team and start designing a project. We’ll help drive your research forward with the right tools for your investigative needs.

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Create, Manage and Track Your Project

Keep an eye on all the various methods and platforms we’re using to ensure your starting material will produce the most in-depth information possible. It’s easy to get in touch with us if you have a question or concern. Then, reach out to our bioinformatics scientists to dig deeper into the results.

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Get Your Data and Analysis Reports

Securely access your raw data and view detailed analyses specific to your scientific question all in one place. Then reach out to our bioinformatics scientists to dig deeper into the results.

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Go to Our Customer Portal

Ready to get started on a project or check in on an existing one. Do that — and more.

Let's Go!

PSO Resourceful!

Want to make your whole-exome sequencing project more efficient and cost-effective?

Other Targeted Sequencing Services

Analyze specific sequences with greater depth — utilizing hybrid capture probe panels — and a variety of other targeted sequencing options.

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Targeted Sequencing

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Bioinformatics

The best techniques for analyzing masses of biological data. Draw meaningful conclusions and uncover insights that help determine gene and protein evolution and function.

Whole-Exome Sequencing