What Is Epigenomics?
Epigenomics is the study of epigenetic changes — such as chromatin assembly, histone modification, and DNA-protein interaction — in a cell.
These modifications are different between different cell types and can affect gene translation and gene expression without changing the DNA sequence.
Why Is Studying Epigenomics Important?
Genetic disorders, metabolic disorders, cancers, degenerative diseases, and changes in plant plasticity have all been linked to epigenetic errors.
Studying the locations and understanding how reversible compound interactions influence genome expression can help scientists recognize the mechanisms by which genes are turned on or off in a disease.
What Can You Do?
Build a comprehensive epigenetic analysis to identify new biomarkers and therapeutic targets.
Understand the role heritability, environment, and behavior play in gene expression and cell differentiation.
Chromatin Immunoprecipitation Sequencing (ChIP-Seq)
Identifying genome-wide binding sites of DNA-associated proteins such as transcription factors or histone modifications
Identifying DNA-binding protein interactions across the entire genome, and understanding the regulation of biological processes in the context of disease
Assay for Transposase Accessible Chromatin Sequencing (ATAC-Seq)
Mapping genome-wide chromatin accessibility by detecting open chromatin regions
Provides detailed insight regarding what areas of the DNA are available for interaction with transcriptional factors that play a role in gene expression regulation
Custom Methylation Sequencing
Assessing methylation patterns using commercially available or custom hybrid capture approaches
Focus on the scientist's regions of interest which will require less sequencing depth
Why Our Clients Choose Psomagen
Superior Data Quality
Exceeds manufacturer benchmarks
Starting at one week for sequencing projects
Sequencing and customer support in Rockville, MD
Ph.D. Level Support
Expert assistance every step of the way, with real-time project updates through our online system
Increase scalability and improve reproducibility
CLIA-Certified, CAP-Accredited Labs
Clinical research options available (inquire for more information)
Complete Sequencing Solutions
From extraction to data analysis, with many sample types accepted