Epigenomics

Examine the impact of epigenomic modifications that cause diseases and disorders in plants, animals, and humans.

What is Epigenomics?

Epigenomics is the study of epigenetic changes — such as chromatin assembly, histone modification, and DNA-protein interaction — in a cell.

These modifications are different between different cell types and can affect gene translation and gene expression without changing the DNA sequence.

Why is Studying Epigenomics Important?

Genetic disorders, metabolic disorders, cancers, degenerative diseases, and changes in plant plasticity have all been linked to epigenetic errors.

Studying the locations and understanding how reversible compound interactions influence genome expression can help scientists recognize the mechanisms by which genes are turned on or off in disease.

What Can You Do?

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Interrogate Disease

Build a comprehensive epigenetic analysis to identify new biomarkers and therapeutic targets.

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Identify Modifiers

Understand the role heritability, environment, and behavior play in gene expression and cell differentiation.

Tools for Studying Epigenomics

Whole Genome Bisulfite Sequencing (WGBS)

Best for:
Profiling genome-wide methylation of DNA that represses transcription and gene expression
Benefits:
Methylated cytosine bases are protected and resulting DNA can be sequenced using various methods

Reduced Representation Bisulfite Sequencing (RRBS)

Best for:
Profiling genome-wide methylation on a single nucleotide scale using a restriction enzyme digestion at CpG sites
Benefits:
Enriched for regions of high methylation, resulting in a greater resolution of the regions of interest

Chromatin Immunoprecipitation Sequencing (ChIP-Seq)

Best for:
Identifying genome-wide binding sites of DNA-associated proteins such as transcription factors or histone modifications
Benefits: Identifying DNA-binding protein interactions across the entire genome, and understanding the regulation of biological processes in the context of disease

Assay for Transposase Accessible Chromatin Sequencing (ATAC-Seq)

Best for:
Mapping genome-wide chromatin accessibility by detecting open chromatin regions
Benefits:
Provides detailed insight regarding what areas of the DNA are available for interaction with transcriptional factors that play a role in gene expression regulation

Ready for the Next Step?

Here's a little information on our ordering process.

If you're already a customer, you can skip to ordering by clicking below.

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Request a Consultation or Quote

Get in touch with your local field team and start designing a project. We’ll help drive your research forward with the right tools for your investigative needs.

Let's Talk!

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Create, Manage and Track Your Project

At this step you'll be able to keep an eye on all the various methods and platforms we’re using to ensure your starting material will produce the most in-depth information possible. It’s easy to get in touch with us if you have a question or concern.

Reach Out!

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Get Your Data and Analysis Reports

Securely access your raw data and view detailed analyses specific to your scientific question all in one place. Then reach out to our bioinformatics scientists to dig deeper into the results.

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Go to Our Customer Portal

Ready to get started on a new project or check in on an existing one? Do that — and more in our customer portal.

Let's Go!

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Make It PSO!

Will epigenome sequencing help you evaluate the role of genome markers in your research?

More PSOmics Solutions

Epigenomics is just one field of study within the omics landscape. Learn how we are helping answer specific questions in other areas.

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