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Omics Research

Epigenomics

Examine the impact of epigenomic modifications that cause diseases and disorders in plants, animals, and humans.

Let's Talk About Epigenomics

What is Epigenomics?


Epigenomics is the study of epigenetic changes — such as chromatin assembly, histone modification, and DNA-protein interaction — in a cell.

These modifications are different between different cell types and can affect gene translation and gene expression without changing the DNA sequence.

 

Why is Studying Epigenomics Important?

 

Genetic disorders, metabolic disorders, cancers, degenerative diseases, and changes in plant plasticity have all been linked to epigenetic errors.

Studying the locations and understanding how reversible compound interactions influence genome expression can help scientists recognize the mechanisms by which genes are turned on or off in disease.

What Can You Do?

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Interrogate Disease

Build a comprehensive epigenetic analysis to identify new biomarkers and therapeutic targets.

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Identify Modifiers

Understand the role heritability, environment, and behavior play in gene expression and cell differentiation.

Tools for Studying Epigenomics

Whole Genome Bisulfite Sequencing (WGBS)
  • Best for:
    Profiling genome-wide methylation of DNA that represses transcription and gene expression

  • Benefits:
    Methylated cytosine bases are protected and resulting DNA can be sequenced using various methods

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Reduced Representation Bisulfite Sequencing (RRBS)
  • Best for:
    Profiling genome-wide methylation on a single nucleotide scale using a restriction enzyme digestion at CpG sites

  • Benefits:
    Enriched for regions of high methylation, resulting in a greater resolution of the regions of interest

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Chromatin Immunoprecipitation Sequencing (ChIP-Seq)
  • Best for:
    Identifying genome-wide binding sites of DNA-associated proteins such as transcription factors or histone modifications

  • Benefits: Identifying DNA-binding protein interactions across the entire genome, and understanding the regulation of biological processes in the context of disease

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Assay for Transposase Accessible Chromatin Sequencing (ATAC-Seq)
  • Best for:
    Mapping genome-wide chromatin accessibility by detecting open chromatin regions

  • Benefits:
    Provides detailed insight regarding what areas of the DNA are available for interaction with transcriptional factors that play a role in gene expression regulation

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