What Is Spatial Biology?
Spatial biology is the analysis of cells within their native tissue environments.
This can be a single RNA or protein visualized on the tissue or mapping of the subcellular coordinates of every RNA transcript and protein within the individual cells that make up the tissue.
Why Is Spatial Biology Important?
Understanding the programs that are operating in each cell and being able to compare that to neighboring cells has far reaching implications for health and disease. Knowing what defines a healthy cell and tracking changes in its transcriptome and proteome while it progresses to a diseased state is leading to the development of new clinical diagnostics and therapeutics.
The newest technologies are so specific and sensitive that every single mRNA or protein can be located inside its cell within its tissue. For example, the 10X Genomics Xenium can even distinguish between different splice variants of the same mRNA.
What Can You Do?
Systems Biology
Map cell-to-cell relationships in multiple dimensions.
Disease Research
Identify novel biomarkers and potential therapeutic targets. Illuminate mechanisms of action or delivery efficiency.
Multiomics
Combine transcriptomics, proteomics, and spatial biology to generate a reference atlas for future research.
Our Platforms
Xenium Panels with a CSP
10x Genomics Xenium panels are predesigned, validated, and curated to identify and characterize cells from human or mouse samples. Off-the-shelf panels are ready to ship. You can add up to 100 custom targets to any panel with 10x Genomics’ expert guidance.
As a 10x Genomics Certified Service Provider, Psomagen labs have the training and experience to help you explore:
- Human Breast
- Human Brain
- Human Lung
- Human Colon
- Human Skin
- Human Multi-Tissue and Cancer
- 5k Human
- Human Immuno-Oncology
- Mouse Brain
- Mouse Tissue Atlassing
- 5k Mouse
Expand Spatial with CosMx
Developed by NanoString Technologies, the CosMx Spatial Molecular Imager provides multiomic insights at cellular and subcellular resolution. With exploratory capabilities and RNA and protein panels, there's no limit to what you'll discover.
Start your spatial journey at Psomagen with any of these panels:
- Human Single-Cell Spatial RNA Analysis 6,000-plex
- Human Single-Cell Spatial RNA Analysis 1,000-plex
- Immuno-Oncology Human Single-Cell Spatial RNA Analysis 100-plex
- Immuno-Oncology Human High Resolution Spatial Proteomic Analysis
- Neurology Mouse Single-Cell Spatial RNA Analysis 1,000-plex
- Neurology Mouse High Resolution Spatial Proteomic Analysis
- Mouse Spatial RNA Analysis 1,000-plex
CytAssist for Visium HD and Visium v2
10x Genomics CytAssist allows for whole transcriptome coverage with high precision
barcode capture. Visium HD with 2µM resolution and whole transcriptome coverage is
an excellent tool for discovery projects.
We offer complete packages including histology and pathology.
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Need Help Choosing Your Spatial Platform?
Why Our Clients Choose Psomagen
Superior Data Quality
Exceeds manufacturer benchmarks
Fast Turnaround
Starting at one week for sequencing projects
US-Based Processing
Sequencing and customer support in Rockville, MD
Ph.D. Level Support
Expert assistance every step of the way, with real-time project updates through our online system
Automated Workflows
Increase scalability and improve reproducibility
CLIA-Certified, CAP-Accredited Labs
Clinical research options available (inquire for more information)
Complete Sequencing Solutions
From extraction to data analysis, with many sample types accepted
Third Generation Sequencing Is Here!
See how the newest technologies are providing deeper insights in omics research.
Omics Insights Blog
March 5, 2025
