<img alt="" src="https://secure.intelligent-consortium.com/791519.png" style="display:none;">
Omics Research // Single-Cell/Spatial Omics

Spatial Biology

See what you discover with the ultimate systems biology tool. Uncover
mechanisms at the level of organs, tissues, cells, and sub-cellular structures.

What Is Spatial Biology?

Spatial biology is the analysis of cells within their native tissue environments.

This can be a single RNA or protein visualized on the tissue or mapping of the subcellular coordinates of every RNA transcript and protein within the individual cells that make up the tissue.

person

Why Is Spatial Biology Important?

Understanding the programs that are operating in each cell and being able to compare that to neighboring cells has far reaching implications for health and disease. Knowing what defines a healthy cell and tracking changes in its transcriptome and proteome while it progresses to a diseased state is leading to the development of new clinical diagnostics and therapeutics.

The newest technologies are so specific and sensitive that every single mRNA or protein can be located inside its cell within its tissue. For example, the 10X Genomics Xenium can even distinguish between different splice variants of the same mRNA.

logo-icon
What Can You Do?
biotech-1

Systems Biology

Map cell-to-cell relationships in multiple dimensions.

coronavirus-1

Disease Research

Identify novel biomarkers and potential therapeutic targets. Illuminate mechanisms of action or delivery efficiency.

workspaces

Multiomics

Combine transcriptomics, proteomics, and spatial biology to generate a reference atlas for future research.

CosMx 6k Is Here!

The 6,000-plex Human Single-Cell Spatial RNA Analysis panel is available to Psomagen customers! With more targets than any other spatial panel on the market, this is the ideal choice for discovery and atlasing projects.

Our Platforms

Untitled design

Xenium Panels with a CSP

10x Genomics Xenium panels are predesigned, validated, and curated to identify and characterize cells from human or mouse samples. Off-the-shelf panels are ready to ship. You can add up to 100 custom targets to any panel with 10x Genomics’ expert guidance.

As a 10x Genomics Certified Service Provider, Psomagen labs have the training and experience to help you explore:

More on Xenium

2

Expand Spatial with CosMx

Developed by NanoString Technologies, the CosMx Spatial Molecular Imager provides multiomic insights at cellular and subcellular resolution. With exploratory capabilities and RNA and protein panels,  there's no limit to what you'll discover. 

Start your spatial journey at Psomagen with any of these panels: 

More on CosMx

Choosing an Instrument

Imaging Platforms

 
10x Genomics
NanoString Technologies
 
Xenium
CosMx RNA
CosMx Protein
Resolution
Subcellular
Subcellular
Subcellular
Capture Area
10.45 x 22.5 mm
FOVs in 15 x 20 mm
FOVs in 15 x 20 mm
Slides per Run
2
2–4
4
Organism
Human (off the shelf)
Mouse (off the shelf)
Custom (any)
Human (off the shelf)
Mouse (off the shelf)
Custom (any)
Human (off the shelf)
Mouse (off the shelf)
Custom (any)
Tissue Type
FFPE
FF
FFPE
FF
FFPE
FF
Slide
10x Genomics
Leica Bond Plus
Leica Bond Plus
Target
Gene Expression
RNA
Gene Expression
RNA
Protein Expression
Protein
Off the Shelf Panels
5,000-plex RNA
100–6,000-plex RNA
64-plex protein
Custom Add-ons
Up to 100 RNA
7–200 RNA
Up to 8
Stand Alone Custom Panels
480–plex RNA
300-plex RNA
N/A

 

Transcriptomic Platforms

 
10x Genomics
STOmics
Curio Trekker
 
Visium HD
Visium CytAssist
Stereo-Seq
Slide-Seqv2
Resolution
2-8µm
55µm
0.5-2µm
10µm
Capture Area
6.5 x 6.5 mm
6.5 x 6.5 mm
11 x 11 mm
10 x 10 mm
20 x 20 mm
30 x 50 mm
60 x 60 mm
130 x 130 mm
3 x 3 mm
10 x 10 mm
Sections per Run
2
2
1
1
Organism
Human
Mouse
Human
Mouse
All
All
Tissue Type
FFPE
FFPE
FF
FFPE
FF
FF
Slide
Positively charged
Positively charged
STOmics provided
Curio provided
Capture Method
Probe-based
Probe-based
Oligo dT
Oligo dT
Sequencing Options
Illumina
CGI
Element
Ultima
Illumina
CGI
Element
Ultima
CGI
Illumina
Read Depth
275M
125M
350M
1.5B
3.0B
400M
2.0B
QC Requirements
RIN >7
DV200>30%
RIN>7
DV200>30%
Tapestation & PicoGreen
RIN>7
Transcripts per Spot
11M
5K (6.5 mm)
14K (11 mm)
100M (0.5 cM x 0.5 cM)
6,000 (3 cM x 5 cM)
200K-500k

 

Spatial Biology Best Practices

Sample Types

A wide variety of sample types are suitable for spatial analysis. Whether starting from fresh frozen tissue in a tube or formalin-fixed paraffin-embedded sections dried onto Xenium slides, high quality spatial data is achievable.

Data Delivery

Standard report includes H&E QC images, decoded data containing cell clusters, transcripts per cell, and differential gene expression.

We're Ready for Your Order!

Here's what to expect in your project's life cycle. If you have a question during sequencing, it's easy to get in touch!

01

Request a Consultation

Create an account through our client portal and get in touch with your local field team to start designing a project.

We’ll help drive your research forward with the right tools for your research needs.

02

Place an Order

After finalizing the scope of work, the official quote will be issued for signing. Then, your sales representative will send specific shipping instructions.

Once all the samples and necessary documents are ready, we can start your project. Need more analysis? Reach out to our bioinformatics experts to dig deeper.

03

QC and Data Delivery

All Psomagen sequencing projects come with a built-in QC step to ensure you get the information you need. An account manager will update you on your project's progress in a timely manner.

You can also see some project information and securely view all valid reports on the client portal site.

New to Spatial Biology?

Experimental design in a new area like spatial biology can be challenging. Take advantage of expert resources to plan for success.

Why Our Clients Choose Psomagen

star

Superior Data Quality

Exceeds manufacturer benchmarks

schedule

Fast Turnaround

Starting at one week for sequencing projects

local-shipping

US-Based Processing

Sequencing and customer support in Rockville, MD

school

Ph.D. Level Support

Expert assistance every step of the way, with real-time project updates through our online system

schema

Automated Workflows

Increase scalability and improve reproducibility

workspace-premium

CLIA-Certified, CAP-Accredited Labs

Clinical research options available (inquire for more information)

stream

Complete Sequencing Solutions

From extraction to data analysis, with many sample types accepted

PSO Multiomic!

How multiomic is your approach? See how our service offerings can work together for research like never before.