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Services

Omics Services

Research Services
Genomics
Metagenomics
Epigenomics
Research Services
Spatial Biology
Single-Cell Sequencing
Proteomics
Long Read Sequencing
Bioinformatics
Capabilities
Resources
Promotions
Support
About Us
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About

CAG and C9orf72 Repeat Analysis

Fast, accurate repeat length analysis for CAG (Huntington’s Disease) and C9orf72 (FTD/ALS), supporting research and model development.

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CAG Repeat Analysis

The CAG assay is indispensable for researchers studying Huntington's disease (HD) and other CAG repeat disorders. These links to HD are primarily found in Exon 1 of the HTT gene. CAG analysis is a critical step in establishing your HD research model, and is optimized to provide single-repeat resolution, ensuring highly accurate data for research decisions. 

Before you start your main study, we offer one free pilot study sample to verify compatibility and performance. If you want to send more than one sample, please contact us for discounted pilot run options!

Workflow

1. Sample submission
2. PCR amplification (HTT gene)
3. CE & fragment analysis
4. Data interpretation
5. Report

Turnaround Time

3–5 business days

Deliverables

1. Report with CAG repeat length
2. Raw data (.fsa file)
3. PDF Peak Plot

Key Features & Detection Range

We provide accurate, single-repeat resolution for alleles containing up to 200 repeats.

Repeat Count Range Repeat Status
1–200 repeats Analytical Reportable Range
Over 200 repeats Categorized as greater than 200 repeats

Pricing

$139 per sample, no minimum order required. Volume discounts may apply. Additional charges for tissue or cell gDNA extraction ($30). 

Sample Requirements

Specifications Requirements
Sample Type Genomic DNA preferred, cells or tissue also acceptable
Quality Check OD260/280≥1.8 and OD260/230≥2.0
Concentration 20–40 ng/µL
Volume 15 µL

Shipping Best Practices

Ship on dry ice to avoid degradation. 

Why Our Clients Choose Psomagen

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Superior Data Quality

Exceeds manufacturer benchmarks

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Fast Turnaround

3-5 days for CAG and C9orf72 assays

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US-Based Processing

Sequencing and customer support in Rockville, MD

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Expert Support

Expert assistance every step of the way, with real-time project updates through our online system

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Automated Workflows

Increase scalability and improve reproducibility

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CLIA-Certified, CAP-Accredited Labs

Clinical research options available (inquire for more information)

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Complete Sequencing Solutions

From extraction to data analysis, with many sample types accepted

C9orf72 Repeat Analysis

Our C9orf72 Repeat Assay is purpose-built for researchers studying Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). As reported by Renton et al. the GGGGCC hexanucleotide repeat expansion in C9orf72 is the most common genetic cause of familial ALS (∼40%), FTD (∼25%), and ALS/FTD (∼90%).

Workflow

1. Sample submission
2. PCR amplification (C9orf72 gene)
3. CE & fragment analysis
4. Data interpretation
5. Report

Turnaround Time

3–5 business days

Deliverables

1. Report with G4C2 repeat length
2. Raw data (.fsa)
3. PDF Peak Plot

Key Features & Detection Range

The assay is optimized to provide single-repeat resolution, ensuring highly accurate data for research decisions. We can precisely detect and size up to approximately 145 G₄C₂  repeats.

Repeat Count Range Repeat Status
1–145 repeats Analytical Reportable Range
Over 145 repeats Categorized as greater than 145 repeats

*If your project requires higher-resolution quantification for expansions expected to exceed 145 repeats, we can discuss alternative approaches using our NGS platform to fully support advanced C9orf72 analysis.

Pricing

$249 per sample, minimum 10 samples per order or $2,490 per order (even with an order of fewer than 10 samples, charge for 10 samples will apply). 

Sample Requirements

Specifications Requirements
Sample Type Genomic DNA preferred, cells or tissue also acceptable
Quality Check OD260/280≥1.8 and OD260/230≥2.0
Concentration 10–40 ng/µL
Volume 15 µL

Shipping Best Practices

Ship on dry ice to avoid degradation. 

CLIA Use

The C9orf72 assay is for research use only. If you require CLIA use of this assay, please reach out to discuss your project and initiate an order. CLIA orders require a physician's test request form. All CLIA orders must be created by our Technical Support team.