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Omics Research

Long-Read Sequencing

See what's possible with third generation sequencing technologies. With long-read sequencing, it's easier than ever to access large, complex DNA and RNA regions.

What Is Long-Read Sequencing Technology?

Long-read sequencing involves the sequencing of DNA or RNA molecules with extended read lengths, typically exceeding tens of thousands base pairs.

PacBio's long-read technology uses a single DNA molecule, thousands of nucleotides long, to produce individual DNA or RNA reads up to 20,000 bases. This can include information about epigenetic modifications — without extra bioinformatics steps.


Why Is Long-Read Sequencing Important?

Extended read length allows researchers to capture complex genomic regions, characterize structural variations, identify epigenetic modifications, and decode hard-to-sequence regions.

This can generate more accurate genome assemblies, better understanding of genetic variations, and enhanced insights into various biological processes. These benefits have applications from medicine to genomics research.

What Can You Do?

Comprehensive Genome Assembly

Reconstruct or generate de novo genomes with fewer errors and areas of uncertainty, even in areas of high homology.


Haplotype Phasing

Obtain a complete and accurate representation of each copy of the genome or region of interest.


Variant Detection

Reach difficult to detect genomic regions, like high GC regions or large insertion-deletion areas. Link phenotypes to novel genes and causative variants.



Get methylation data from your sample without extra steps or protocols. Take simultaneous advantage of haplotype-phased and variant-called genomic information.

Our Services

Whole Genome Sequencing

Obtain the complete DNA information of an organism, encompassing even the most challenging-to-sequence regions, with remarkable precision and unbiased representation. Identify genetic variations, perform de novo sequencing, analyze structural genomic changes, and investigate epigenetic details.

Single-Cell Transcriptomics

Uncover the diversity of RNA at the isoform level, which holds immense importance for both fundamental research and studying diseases.

With PacBio MAS-Seq, you can sequence entire RNA isoforms within individual cells, accompanied by unique single-cell barcodes and UMI data. This approach provides unparalleled insights into the intricacies of single-cell biology.

Targeted Sequencing

Using Twist Bioscience's target enrichment kits in conjunction with PacBio's long-reads technology, you gain an adaptable and cost-effective solution for achieving comprehensive coverage of challenging genomic regions.

This method offers a robust alternative for scaling up your sequencing efforts.


Access details about microbial communities and microbiomes with shotgun metagenomic profiling and assembly using long-read sequencing. Accurately characterize the functional aspects and taxonomy of microbial communities or access full-length 16S sequences to acquire information at the species/strain level.

Run Your Long Reads on the Revio

Psomagen has PacBio's latest sequencing instrument — see what you can discover with a 15x increase in read throughput. 

Long-Read Best Practices

Sample Types

We accept numerous sample types for our long-read technology, not limited to:

  • Cultured cells and bacteria
  • Blood
  • Plants
  • Tissue

Regardless of the starting material, it is possible to attain high quality, accurate results. We also offer extraction services for your convenience.

Expected Output

Each SMRT Cell can produce up to 90 Gb of total long-read sequencing data, a phased 30x whole human genome, up to 80 million full-length RNA isoforms, and approximately 170 HQ-MAGs from a human gut microbiome sample.

Data Delivery

Standard report includes sequence data and QC results. Depending on your needs, we can include variant calling, mapped files, methylation information and more.

We're Ready for Your Order!

Here's what to expect in your project's life cycle. If you have a question during sequencing, it's easy to get in touch!


Request a Consultation

Create an account through our client portal and get in touch with your local field team to start designing a project.

We’ll help drive your research forward with the right tools for your research needs.


Place an Order

After finalizing the scope of work, the official quote will be issued for signing. Then, your sales representative will send specific shipping instructions.

Once all the samples and necessary documents are ready, we can start your project. Need more analysis? Reach out to our bioinformatics experts to dig deeper.


QC and Data Delivery

All Psomagen sequencing projects come with a built-in QC step to ensure you get the information you need. An account manager will update you on your project's progress in a timely manner.

You can also see some project information and securely view all valid reports on the client portal site.

Why Our Clients Choose Psomagen


Superior Data Quality

Exceeds manufacturer benchmarks


Fast Turnaround

Starting at one week for sequencing projects


US-Based Processing

Sequencing and customer support in Rockville, MD


Ph.D. Level Support

Expert assistance every step of the way, with real-time project updates through our online system


Automated Workflows

Increase scalability and improve reproducibility


CLIA-Certified, CAP-Accredited Labs

Clinical research options available (inquire for more information)


Complete Sequencing Solutions

From extraction to data analysis, with many sample types accepted

PSO Multiomic!

How multiomic is your approach? See how our service offerings can work together for research like never before.